The A35 was closed due to a crash involving a lorry and a car.
Emergency services rushed to Charmouth after receiving a report of a two-vehicle crash.
The fire service were at the scene trying to rescue two people from one of the vehicles.
The route was blocked in both directions at the Charmouth turn-off.
The A35 was closed between Charmouth and Lyme Regis, with traffic being re-directed through Charmouth village.
An air ambulance was also seen circling the area and landed at around 3.41pm.
A spokesperson for Dorset and Wiltshire Fire and Rescue said: We were called at 2.29pm to reports of a two-vehicle road traffic collision.
"One crew from Charmouth and two crews from Bridport attended where they are currently using hydraulic tools to release two people from one of the vehicles. We are still currently in attendance.
A spokesperson for Dorset Police said: "We were called at 2.25pm to a report of a two vehicle collision on the A35 near Charmouth.
"Officers in attendance with ambulance and fire services.
"Road closures are in place."
Police have been asked for more information.
The road was cleared at around 6.30pm.
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